Interleukin-17 (IL-17)-mediated immunity controls skin infection and T helper 1 response during experimental Microsporum canis dermatophytosis

CHIAPELLO, LS

JOURNAL OF INVESTIGATIVE DERMATOLOGY

NATURE PUBLISHING GROUP

Lugar: Londres; Año: 2018

0022-202X

espite worldwide prevalence of superficial mycoses, the immune response indermatophytosis has scarcely been investigated. In this study, we developed a model of superficial skin infection in C57BL/6 mice with Microsporum canis, a highly prevalent human pathogen. This model mimics mild inflammatory human dermatophytosis, characterized by neutrophil recruitment and fungal invasion limited to the epidermis, and exhibits the establishment of a specific T helper 17 (Th17) immune response during infection. By using IL-17RA or IL-17A/F deficient mice we showed that, in the absence of a functional IL-17 pathway, M. canis extensively colonizes the epidermis and promotes an exaggerated skin inflammation and a shift to an IFN-γ-mediated (Th1) response. Strikingly, IL-17 signaling was not involved in neutrophil influx to skin or fungal invasion to deeper tissues. Finally, this study demonstrates that skin langerinexpressingcells contribute to the antifungal Th17 response in vivo.In conclusio