Quantitative proteomic analysis of epithelial cells of the female genital tract identifies Type I Interferons pathway as relevant in the host response against Candida albicans

RODRIGUEZ, EMILSE; ANGIOLINI, SOFIA CARLA; HERNANDEZ, MARÍA LUISA; ICELY, PAULA ALEJANDRA; STEMPIN, CINTHIA; VARGAS, LARA; GIL GARCÍA, CONCHA; SOTOMAYOR, CLAUDIA ELENA

Córdoba

Congreso; XIX Forum on Fungal Infection in the Clinical Practice, INFOCUS 2021; 2021

INFOCUS and ISHAM

Vulvovaginal candidiasis (VVC) is an acute inflammatory disease caused primarily byCandida albicans (Ca). VVC affects more than 75% of healthy women at least once in theirlifetime. Despite the extensive knowledge about host predisposing factors, many of themechanisms that govern the complex Ca-Epithelial Cell (EC) interaction and the immunemediators involved in the response to the fungus have not been completely clarified. Type Iinterferons (IFNs-I) have been traditionally associated with antiviral immune responses,however, their importance in host defense against fungal pathogens is being increasinglyappreciated. At present, it is not well known the role of IFNs-I in Ca infections at mucosallevel, especially in the cervicovaginal tract.