RAMAN, SERS AND UV - CIRCULAR DICHROISM SPECTROSCOPIC STUDY OF N-ACETYL-L-CYSTEINE IN AQUEOUS SOLUTIONS

TUTTOLOMONDO, MARÍA EUGENIA

NEW JOURNAL OF CHEMISTRY

ROYAL SOC CHEMISTRY

Lugar: CAMBRIDGE; Año: 2019 vol. 43 p. 15201 - 15201

1144-0546

he aim of this work is to evaluate the vibrational and structural properties of N-acetyl-L-cysteine (NAC), and its molecular structure and electronic properties in relation to the action of thiol and amine groups at different pH. Raman and Surface Enhanced Raman Spectroscopy (SERS) spectra were measured in aqueous solution. The influence of an aqueous environment on the NAC spectra was simulated by means of an implicit (polarizable continuum model) method. SERS spectra indicate that the S atom is interacting with the surface through the sulfur atom. One of the consequences of the interaction with the surface is the deprotonation of the SH group, as revealed by the disappearance of the n(S?H) band.The calculations performed for the Ag?NAC complex confirm the experimental data obtained by SERS, where the S?Ag interaction is the most important. These results are very interesting when one can formulate the drug feasibility of NAC using silver nanoparticles as a carrier. Raman spectr