Derivatives of Solanocapsine as inhibitors of Acetylcholinesterase.

JOSÉ L. BORIONI; MANUELA E. GARCÍA; VALERIA CAVALLARO; ANA P. MURRAY; ALICIA B. PEÑÉÑORY; MARCELO PUIATTI; ADRIANA B. PIERINI

Santiago de Chile

Congreso; 10th Congress of the World Association of Theoretical and Computational Chemists; 2014

World Association of Theoretical and Computational Chemists

A series of new derivatives of solanocapsine were synthesized and their inhibitory activities on AChE tested. Structure-activity relationships through molecular docking studies and molecular dynamics were then discussed. Based on these results new derivatives are proposed.
~