QUEVEDO MARIO ALFREDO
Congresos y reuniones científicas
Título:
Complexation between doxycycline hyclate and b-cyclodextrin. Experimental and theoretical studies
Autor/es:
KOGAWA, A.C.; ZOPPI, A.; QUEVEDO, M.A.; NUNES SALGADO, H.R.; LONGHI, M.R.
Lugar:
Riberão Preto
Reunión:
Congreso; 8th International Congress of Pharmaceutical Sciences; 2011
Institución organizadora:
Comité Organizador del 8vo. Congreso Internacional de Ciencias Farmacéuticas
Resumen:
Doxycycline (DOX) is a drug effective against a large variety of bacteria. In addition, it has
antiprotozoal actions and may be administered in conjunction with quinine in the management
of falciparum malaria. Unfortunately DOX is quite susceptible to light, thus diverse strategies
towards increasing its photostability are envisioned. A commonly applied approach to
increase the stability of drugs is the formation of complexes with macromolecules, of which
molecular encapsulation with β-cyclodextrin (βCD) constitutes an alternative for the
development of new pharmaceutical dosage forms. The objective of this work was to
investigate the possibility of obtaining an inclusion complex between DOX and βCD in
order to enhance this drug stability, by combining both experimental and theoretical
approaches.
antiprotozoal actions and may be administered in conjunction with quinine in the management
of falciparum malaria. Unfortunately DOX is quite susceptible to light, thus diverse strategies
towards increasing its photostability are envisioned. A commonly applied approach to
increase the stability of drugs is the formation of complexes with macromolecules, of which
molecular encapsulation with β-cyclodextrin (βCD) constitutes an alternative for the
development of new pharmaceutical dosage forms. The objective of this work was to
investigate the possibility of obtaining an inclusion complex between DOX and βCD in
order to enhance this drug stability, by combining both experimental and theoretical
approaches.
