Exploring Efavirenz supramolecular complexes to reduce Staphylococcus aureus virulence and resistance factors

FUMAROLA, MELISA A

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

EDITIONS SANTE

Lugar: London; Año: 2025 vol. 104

1773-2247

ntimicrobial resistance represents a significant global challenge that demands the development of innovative pharmaceutical strategies. Efavirenz, an antiviral drug, also exhibits antivirulence and antibiofilm effects on Staphylococcus aureus. However, efavirenz oral bioavailability is low and variable, limited by its poor aqueous solubility. In this study, the complexation of efavirenz with α-cyclodextrin and meglumine were investigated to identify an optimized delivery system. The characterization of the solids by thermal analysis, scanning electron microscopy, electron probe microanalysis and X-ray diffraction demonstrated the efficacy of the kneading method for the preparation of a multicomponent complex. Dissolution of efavirenz from the supramolecular powders into water containing 1 % sodium lauryl sulfate was measured by UV/Vis absorption spectroscopy. Results show that the complexation leads to the formation of a solid with a significantly better dissolution profile and f