A systematic approach to the synthesis of LDH nanoparticles by response surface methodology

VASTI, CECILIA; PFAFFEN, VALERIA; AMBROGGIO ERNESTO ESTEBAN; GALIANO, MAURICIO; ROJAS, RICARDO; GIACOMELLI, CARLA

APPLIED CLAY SCIENCE

Elsevier Ltd

Año: 2017 vol. 137 p. 151 - 151

0169-1317

he customization of the properties of layered double hydroxides nanoparticles (LDH-NPs) is essential to optimize their design innovative systems for biomedical applications. Response surface methodologies (RSMs), a collection of mathematical and statistical techniques that allows multivariate optimization of processes, are a useful tool for LDH-NPs customization. In this work, RSMs were used to study the synthesis parameters governing the size and composition of Mg[sbnd]Al LDH-NPs (Mg/Al = 3) labeled with fluorescein isothiocyanate (FITC2 −) and prepare customized samples for biological assays. The influence of [Al3 +], [OH−]/[Mg2 ++ Al3 +], 2[FITC2 −]/[Al3 +] and time of the hydrothermal treatment (tHT) was determined by a Box-Behnken experimental design (BBD). The experimental responses were hydrodynamic diameter (dH), polidispersity index (PI) and FITC2 − content (%FITC), and their dependence with the synthesis variables was described by polynomial model. Th