Opposite effects produced by Magnetic Nanoparticles:Phospholipid films generated at a liquid/liquid interface, in the drug transfer processes

SARA NATALIA MOYA BETANCOURT

ELECTROCHIMICA ACTA

PERGAMON-ELSEVIER SCIENCE LTD

Año: 2023 vol. 433 p. 1 - 1

0013-4686

he interaction between Fe3O4 magnetic nanoparticles (MNPs) coated with polysaccharides, and different phospholipids adsorbed at a water|1,2-dichloroethane interface, was studied employing cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS) and capacity curves. For this study, an anionic phospholipid, distearoyl phosphatidic acid (DSPA), and a zwitterionic phospholipid distearoyl phosphatidylethanolamine (DSPE) were used, which have the same carbonated chain. Fe3O4 nanoparticles were coated with two different polysaccharides, one lineal, chitosan (CHI), and other with a branched structure, diethylaminoethyl dextran (DEAE-D), both commonly used in medical applications. The effect of the MNPs coating agents in the final interaction with MNPs:phospholipid hybrid films was evaluated. EIS confirm that the presence of Fe3O4@CHI:DSPA mixture film conduces to a homogeneous film at the interface, in contrast, for Fe3O4@DEAE-D:DSPA mixture films, conduces to a inhomogeneous fil