A Crucial Role of INF-gamma in Experimental Autoimmune Prostatitis

MOTRICH RD; VAN ETTEN E; BAEKE F; RIERA CM; MATHIEU C; RIVERO VE

Elsevier

Lugar: Charlottesville; Año: 2010 vol. 183 p. 1213 - 1213

urpose: An autoimmune etiology is proposed in some patients with chronicnonbacterial prostatitis since they show IFN-gamma secreting lymphocytes specific toprostate antigens in the periphery and increased IFN-gamma in seminal plasma. Weinvestigated the involvement of IFN-gamma in an animal model of autoimmune prostatitis.Materials and Methods: Experimental autoimmune prostatitis was studied inthe no-obese diabetic and C57Bl/6 (Harlan, Zeist, The Netherlands) susceptiblemouse strains, and in the IRF-1 KO and STAT-1 KO mouse strains deficient intranscription factors involved in IFN-gamma signaling.Results: Experimental autoimmune prostatitis was characterized by prostatespecific IFN-gamma secreting cells in the periphery and by T-helper 1 related cytokinesin the target organ. Increased IFN-gamma and IL-12 were observed in the prostate ofautoimmune animals while IL-10 and IL-4 were decreased and unaltered, respectively.