Expression of CXCR3 on specific T cells is essential for homing to the prostate gland in an experimental model of Chronic Prostatitis/Chronic Pelvic Pain Syndrome

BRESER, ML; MOTRICH, RD; SANCHEZ, L; MACKERN OBERTI, JP; RIVERO, VE

AMER ASSOC IMMUNOLOGISTS

Lugar: Bethesda; Año: 2013 vol. 190 p. 3121 - 3121

xperimental autoimmune prostatitis (EAP) is considered a valid model for the human disease chronic prostatitis/chronic pelvic pain syndrome. In this report, we analyzed phenotypic characteristics of T cells that gain access to the prostate and induce leukocyte recruitment in mice with different susceptibility to EAP. After EAP induction, NOD mice developed a specific cellular response characterized by a mixed Th1/Th17 pattern with specific T cells mainly expressing CXCR3 that infiltrated and damaged the prostate. In contrast, BALB/c mice, as well as NOD-IFN-g -/-, exhibited only Th17 cells mainly expressing CCR6 that were not capable of infiltrating the prostate gland. Adoptive transfer experiments of T cells from NOD or NOD?IFN-g -/- mice to NOD-SCID recipients showed that only T cells from NOD mice successfully infiltrated the prostate. However, after ?in vitro? or ?in vivo? treatment with rIFN-g, T cells from NOD?IFN-g -/- mice became capable of homing to the prostate and induced l