Effect of tamoxifen treatment on the semen quality and fertility of the male rat

MOTRICH RD; PONCE AA; RIVERO VE

FERTILITY AND STERILITY

Elsevier

Lugar: Los Angeles; Año: 2007 vol. 88 p. 452 - 452

0015-0282

BJECTIVES: To determine the effects of tamoxifen treatment on the seminal quality and fertility of the male Wistar rat. DESIGN: Experimental prospective study. SETTING: Animal research and university laboratory facility. SUBJECT(S): Seventy-five-day-old male and female Wistar rats. INTERVENTION(S): Sperm quality parameters were assayed in seminal and epididymal sperm samples in control and treated rats at a dose of 0.4 mg tamoxifen/kg per day. In addition, mating studies were performed, and different fertility parameters were assayed. RESULT(S): Tamoxifen treatment significantly decreased sperm concentration and motility in seminal and epididymal sperm. Sperm viability and hypo-osmotic swelling test results were shown not to be altered. The copulatory plug was absent or severely impaired in tamoxifen-treated males. When mating experiments were performed, a significant decrease in the fertility index and increased percentages of preimplantation and postimplantation embryo