Resumen:
hronic non bacterial prostatitis is a chronic inflammatory syndrome.
Its etiology and physiopathology are unclear and treatments are
empirical and ineffective in most cases. Autoimmunity has been proposed
as an etiology. In the present report, we investigated the impact of
vitamin D receptor silencing, by use of VDR-KO NOD mice and the
immune-modulating effect of the vitamin D3 analog TX527 on the
development of Experimental Autoimmune Prostatitis in NOD mice. VDR-KO
NOD mice developed a more aggressive form of autoimmune prostatitis
characterized by a greater lymphoproliferative response against
prostate antigen in vitro (6.92+/-4.77 vs. 2.47+/-0.41 21 days after
disease induction, p<0.05) and higher levels of specific INFgamma
secretion (471+/-6 vs. 386+/-5pg/ml, p<0.01). This was accompanied
in vivo by more severe lesions and augmented mononuclear cell
infiltration in the prostate gland. On the other hand, although
analog-treated mice showed a significant reduct