Artículos
Título:
Autoimmune prostatitis: state of the art
Autor/es:
MOTRICH RD; MACCIONI M; RIERA CM; RIVERO VE
Revista:
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
Editorial:
Blackwell Publishing Ltd
Referencias:
Lugar: Bergen; Año: 2007 vol. 66 p. 217 - 217
Resumen:
he prostate is one of the main male sex accessory glands and the
target of many pathological conditions affecting men of all ages.
Pathological conditions of the prostate gland range from infections,
chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) of a still
unknown aetiology to benign hyperplasia and cancer. CP/CPPS is one of
the most prevalent diseases in the urologic clinic and affects men
younger than 50 years old. A significant advance in the understanding
of CP/CPPS was made when an autoimmune response against prostate
antigens was revealed in a considerable number of patients. During the
last 30 years, extensive work has been done regarding the development
and characterization of different rodent models of experimental
autoimmune prostatitis (EAP). It has been demonstrated that tolerance
to prostate antigens can be disrupted in some strains of rats and mice
and cellular and humoral responses to prostate antigens are elicited. A
Th1 pattern has been desc