Patients with chronic prostatitis/chronic pelvic pain syndrome show T helper type 1 (Th1) and Th17 self-reactive immune responses specific to prostate and seminal antigens and diminished semen quality.

MOTRICH, RUBEN D.; BRESER, MARIA L.; MOLINA, ROSA; TISSERA, ANDREA; OLMEDO, JOSE J; RIVERO, VIRGINIA E.

BJU INTERNATIONAL.

WILEY-BLACKWELL PUBLISHING, INC

Lugar: Londres; Año: 2020

1464-4096

bjectives: To assess the presence of self-reactive immune responses to seminal and prostate antigens (PAg), biomarkers of inflammation of the male genital tract and semen quality parameters in patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). Subjects and methods: peripheral blood and semen samples were collected from CP/CPPS patients and age-matched healthy control volunteers. The analysis of lymphoproliferative responses of peripheral blood mononuclear cells (PBMC) to different seminal plasma-derived and purified PAg, serum autoantibodies specific to PAg, leukocyte subpopulations and inflammatory cytokines in semen, sperm apoptosis/necrosis, and semen quality parameters were performed. Results: Significantly increased PBMC proliferative responses specific to PAg, with elevated secretion of IFNγ and IL-17, were detected in CP/CPPS patients with respect to controls. Moreover, CP/CPPS patients showed significantly increased serum IgG immune reactivity to s