Chronic Infection of the Prostate by Chlamydia muridarum Is Accompanied by Local Inflammation and Pelvic Pain Development

SANCHEZ, LEONARDO R.; BRESER, MARIA L.; GODOY, GLORIA J.; SALAZAR, FLORENCIA C.; MACKERN-OBERTI, JUAN P.; CUFFINI, CECILIA; MOTRICH, RUBEN D.; RIVERO, VIRGINIA E.

PROSTATE

WILEY-LISS, DIV JOHN WILEY & SONS INC

Lugar: Hoboken; Año: 2017 vol. 77 p. 517 - 517

0270-4137

ACKGROUND: Chlamydia trachomatis urogenital infections are the leading cause of sexually transmitted bacterial infections. Although the prevalence of chlamydial infection is similar in men and women, current research is mainly focused on women, neglecting the study of male genital tract infections. We, therefore, investigated Chlamydia infection in the rodent male genital tract. MATERIALS AND METHODS: Male NOD and C57BL/6 mice were inoculated in the meatus urethra with C. muridarum. Bacterial DNA, leukocyte infiltration of male genital tract tissues, pelvic pain, and Chlamydia-specific immune responses were analyzed at different time points. RESULTS AND CONCLUSIONS: The inoculation of C. muridarum in the meatus urethra of male mice resulted in an ascending and widely disseminated infection of the male genital tract. C. muridarum remained longer and with the highest bacterial burdens in the prostate, thus showing a special tropism for this organ. Infection caused leukocyte infiltration