Toxicological Study Employing Repeated Doses of Garcinielliptone FC, a Polyisoprenylated-Benzophenone Isolated from Seed of Platonia Insignis Mart

ANA P. SILVA; JOSÉ CARLOS C. L. S. FILHO ; JOAQUIM S. DA COSTA JÚNIOR ; WALTER J. PELÁEZ; MARTÍN S. FAILLACE; ALEXANDRE DE B. FALCÃO FERRAZ ; JORGE M. DAVID; RIVELILSON M. FREITAS

JOURNAL OF PHARMACY AND PHARMACOLOGY

David Publishing Company

Lugar: New York; Año: 2015 p. 316 - 316

2328-2150

ttp://www.davidpublisher.com/Home/Journal/JPP http://www.davidpublisher.com/index.php/Home/Journal/detail?journalid=3&jx=JPP&cont=allissues Año: 2015. Issue: 7. DOI: 10.17265/2328-2150/2015.07.002Abstract: The major constituent from the hexane extract of the seeds of P. insignis is GFC (garcinielliptone FC). Doses of 25, 50and 75 mg/kg of GFC were aseptically suspended in 0.05% Tween 80 dissolved in 0.9% saline (vehicle) and orally administered for30, 90 and 120 consecutive days to adult Swiss mice. In this work, the repeated oral administration, in animals of both sexes,demonstrates that this compound is not able to induce mortality and/or behavioral changes in adult mice. In addition, body weightgain, feed intake and disposal of excreta were not altered by the administration of this compound with repeated doses. Furthermore,no differences in weight and macroscopic structure of the brain, liver, kidney, lung, heart and spleen between groups of male andfemale adult mice were observed