Cyclohexene-fused 1,3-oxazines with selective antibacterial and antiparasitic action and low cytotoxic effects

DE BRITO, MARIA R.M.; PELÁEZ, WALTER J.; FAILLACE, MARTÍN S.; MILITÃO, GARDENIA C.G.; ALMEIDA, JACKSON R.G.S.; ARGÜELLO, GUSTAVO A.; SZAKONYI, ZSOLT; FÜLÖP, FERENC; SALVADORI, MARIA C.; TEIXEIRA, FERNANDA S.; FREITAS, RIVELILSON M.; PINTO, PEDRO L.S.; MENGARDA, ANA C.; SILVA, MARCOS P.N.; DA SILVA FILHO, ADEMAR A.; DE MORAES, JOSUÉ

TOXICOLOGY IN VITRO : AN INTERNATIONAL JOURNAL PUBLISHED IN ASSOCIATION WITH BIBRA.

PERGAMON-ELSEVIER SCIENCE LTD

Año: 2017 vol. 44 p. 273 - 273

0887-2333

xazine derivatives, a class of heterocyclic compounds, exhibit a variety of biological properties, such as anticonvulsant and antitumor activities. In this study, we evaluated the effect of two cyclohexene-fused 1,3-oxazines (cis‑1-benzyl-N-phenyl-1,4,4a,5,8,8a-hexahydro-3,1-benzoxazin-2-imine (1) and trans‑N-phenyl-1,4,4a,5,8,8a-hexahydro-3,1-benzoxazin-2-imine (2)) in cultures of Bacillus cereus, Enterococcus faecalis,Escherichia coli,Klebsiella pneumoniae,Salmonella enterica,Serratia marcescens,ShigellaflexneriandStaphylococcusaureus by the Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC).Additionally, theex vivoantiparasitic activity of oxazines was assessed againstSchistosoma mansoni, a helminththat is one of the major agents of the disease schistosomiasis Also, oxazines were evaluated on three tumor celllines, NCI-H292 (human lung carcinoma), MCF-7 (human breast adenocarcinoma) and HEp-2 (human cervixcarcinoma), and two normal cell