Sulfated and Oxygenated Imidazoline Derivatives: Synthesis, Antioxidant Activity and Light‐Mediated Antibacterial Activity

FAILLACE, MARTÍN S.; SILVA, ANA P.; ALVES BORGES LEAL, ANTONIO L.; MURATORI DA COSTA, LUCIANA; BARRETO, HUMBERTO M.; PELÁEZ, WALTER J.

CHEMMEDCHEM

WILEY-V C H VERLAG GMBH

Año: 2020 vol. 15 p. 851 - 851

1860-7179

bstract: Imidazoline derivatives with different exocyclic substituents were simply prepared from common starting materials. The procedures were carried out under an eco-friendly perspective. The antioxidant activity of these derivatives was explored by different experimental assays, such as ABTS●+ and DPPH● scavenging assay, as well as Reducing Power assay. The structural differences are discussed in terms of the results. Then, sulfur analogs showed higher antioxidant activity than the oxygenated counterparts. The same tendency was observed in the microbiological studies, where the same imidazoline compounds were assayed for light-mediated activity against strains of Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli). A light-enhanced activity was observed for almost all the sulfurated imidazolines after exposure to UV-A (400 320 nm) light.