Molecular organization and recognition properties of amphiphilic cyclodextrins.

RITA H. DE ROSSI; OSCAR FERNANDO SILVA; RAQUEL VICO; CARLOS GONZALEZ

INT UNION PURE APPLIED CHEMISTRY

Año: 2009 vol. 81 p. 755 - 755

he continuing challenge of using cyclodextrins (CDs) for solubilization and drugtargeting has led to the preparation of a wide variety of chemically modified derivatives inorder to improve the properties of these host molecules. A possible approach for pharmaceuticalapplications would be to combine the recognition specificity of CDs with the transportproperties of organized structures such as vesicles, liposomes, or micelles.Amphiphilic CDs can be admixed to phospholipid monolayers and to liposomes, andthey can be dispersed into nanospheres showing promising properties for drug encapsulation.Monoacylated derivatives of b-CD, Mod-CD (Cn), were synthesized in our laboratoryfrom the reaction of alkenyl succinic anhydride with b-CD. We found that the compoundwith 10 carbon atoms in the alkenyl chain, Mod-CD (C10), can be incorporated into invertedmicelles. We studied their properties in solution and at the air–water interface. In