Cyclodextrin modified niosomes to encapsulate hydrophilic compounds

MACHADO, NOELIA D.; SILVA, O. FERNANDO; DE ROSSI, RITA H.; FERNÁNDEZ, MARIANA A.

RSC Advances

The Royal Society Chemistry

Año: 2018 vol. 8 p. 29909 - 29909

iosomes were prepared from equimolar mixtures of two non-ionic surfactants, Span 80 and Tween 80. The capability of the vesicular systems was studied through the encapsulation of two azo dyes as molecular probes of different hydrophobicity (methyl orange (MO) and methyl yellow (MY)). To improve the efficiency of the niosomes to encapsulate the dyes, we employed an additional modification of the vesicular system, adding b-cyclodextrin (b-CD) or a modified amphiphilic b-CD (Mod-b-CD) to the niosomes. Neither the inclusion of dyes nor the incorporation of b-CD to the niosomes produces considerable modifications in size and morphology of the vesicles. However, in the presence of Mod-b- CD the niosomes became smaller, probably due to the anchoring of the cyclodextrin at the surface of vesicles through the hydrophobic chain, altering the curvature of the outer monolayer and reducing the surface charge of the interphase. The entrapment efficiency (EE) for MY