NEOVASCULAR RETINOPATHIES: ETIOLOGY AND MODELS OF STUDY FOR SEARCHING NEW THERAPEUTIC TARGETS

RIDANO, ME; LUNA JD; LORENC VE; SUBIRADA, PV; PAZ, MC; VAGLIENTI MV; BARCELONA PF; SANCHE MC

Anales AFA

Número Especial Ciencias de la Visión - inVisionT 2017

Lugar: Buenos Aires; Año: 2018 p. 56 - 56

1850/1168

eovascular retinopathies are the main causes of blindness. In these pathologies, the visual deficit has been caused, at least in part, by an imbalance of angiogenic factors generated by ischemia, which produces neovessel formation and hemorrhages, with a partial or total reduction of vision. Vascular endothelial growth factor A (VEGF-A) is the most studied molecule that mediates retinal neovascularization induced by ischemia in ocular pathologies. Treatments for these retinopathies (photocoagulation, vitrectomy, intraocular injection ofmonoclonal antibodies) try to stop them but only in very specific cases they improve it. Therefore, searching new therapeutic targets is a challenge at present. In this review, we will provide information about the currentknowledge related to etiology of the most prevalent neovascular retinopathies, in vivo and in vitro models to study them and the new therapeutic candidates that have arisen.