LOW-DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN-1 (LRP-1) EXPRESSION IN A RAT MODEL OF OXYGEN-INDUCED RETINOPATHY

SÁNCHEZ MC; BARCELONA PF; LUNA JD; ORTIZ S; JUAREZ PC; RIERA CM; CHIABRANDO GA

EXPERIMENTAL EYE RESEARCH

ELSEVIER

Lugar: Amsterdam; Año: 2006 vol. 83 p. 1378 - 1378

0014-4835

p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt; LINE-HEIGHT: normal; mso-layout-grid-align: none">The low-density lipoprotein receptor-related protein-1 (LRP-1) is a high-molecular weight receptor of the LDL receptor gene family. Its ability to bind and internalize both proteinases and proteinase-inhibitor complexes from the extracellular space suggests that it has a major role in modulating uncontrolled retinal cell proliferation. In order to test this assumption, we investigated the expression of LRP-1 and receptor-associated ligands in a rat model of oxygen-induced retinal neovascularization. Wistar albino rats were placed into incubators at b