ESTUDIO DEL RECEPTOR P75NTR DURANTE LA NEOVASCULARIZACIÓN COROIDEA.

BARCELONA, PF

Buenos Aires

Congreso; AIVO 2021 (XIV Congreso Nacional de Investigación en Visión y Oftalmología).; 2021

In industrialized countries, the most frequent cause of blindness in the elderly is age related macular degeneration (AMD). In the wet form of AMD, neuronal demise is thought to be a consequence of the pro-inflammatory response and the disruption of retinal architecture due to pathological choroidal neovascularization (CNV). Consequently, increased neurodegeneration of rods and cones occurs. However, it is still largely unknown how choroid and retinal cells recruit inflammatory macrophages and how the pro-inflammatory response participates in neurodegeneration and neovascularization. I am working with in vitro and in vivo models (proliferative and non-proliferative) to address neurodegenerative events in the retina. We aim to understand the role of neurotrophins and their receptors in the mechanisms causing these ocular disorders. It is known that the p75 neurotrophin receptor (p75NTR) regulate neuronal apoptosis, remodeling, and synaptic plasticity during development and after injury. In previously work was showed that p75NTR participates in inflammation and vascular alteration. In my work I showed these during diabetic retinopathy and glaucoma, making it potentially relevant to AMD pathology as well. Therefore, our purpose is to understand the basic biology of retinopathies and subsequently target potential pathways involved in its pathogenesis. Our specific aim is to investigate the role of p75NTR during vascular and neuronal alterations in a well characterized mouse model of laser-induced CNV. Our own results show, a significant increase of p75NTR protein expression in retinal and choroid, 7 days after the laser injury, highlighting its participation in this inflammatory animal model.