Comparative study in the asymmetric bioreduction of ketones by

ALEJANDRO A. ORDEN; FABRICIO R. BISOGNO; OSCAR S. GIORDANO; MARCELA KURINA-SANZ

ELSEVIER SCIENCE BV

Año: 2008 vol. 51 p. 49 - 49

font size="1" face="Times-Roman"> Stereoselective reduction of prochiral ketones was studied by using both cell cultures and wild tissues of various endemic plant species. Dedifferentiated cell cultures of Baccharis crispa reduced regioselectively, with excellent stereocontrol, and in an anti-Prelog manner the methyl ketone moiety of a diketone, meanwhile Tessaria absinthioides cell cultures yielded the other antipode of the secondary alcohol with an optical purity higher than 98% ee