Thiol-free chemoenzymatic synthesis of β-ketosulfides

BISOGNO, FABRICIO R

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY

BEILSTEIN-INSTITUT

Lugar: Frankfurt; Año: 2019 vol. 15 p. 378 - 378

1860-5397

preparation of β-ketosulfides avoiding the use of thiols is described. The combination of a multicomponent reaction and a lipase catalysed hydrolysis has been developed in order to obtain high chemical diversity employing a single sulfur donor. This methodology for the selective synthesis of a set of β-ketosulfides is performed under mild conditions and can be set up in one-pot two-step and on a gram-scale