Chemo- and Stereodivergent Preparation of Terminal Epoxides and Bromohydrins through One-Pot Biocatalysed Reactions: Access to Enantiopure Five- and Six-Membered N-Heterocycles

FABRICIO R. BISOGNO

ADVANCED SYNTHESIS & CATALYSIS (PRINT)

WILEY-V C H VERLAG GMBH

Año: 2010 vol. 352 p. 1657 - 1657

1615-4150

font size="2" face="AdvTTR"> Different enantiopure terminal epoxides or bromohydrins have chemoselectively been synthesised in one-pot starting from the correspondingone-pot starting from the corresponding a-bromo ketones through alcohol dehydrogenase (ADH)-catalysed processes adding an organic cosolvent and tuning appropriately the medium pH and the temperature. Thus, at neutral pH enantiopure