Biocatalysis applied to the synthesis of valuable triazole-containing derivatives

ANÍBAL CUETOS; FABRICIO R. BISOGNO; IVÁN LAVANDERA; ORAZIO A ATTANASI; DOMENICO SPINELLI

Targets in Heterocyclic Systems, Chemistry and Properties

ROYAL SOC CHEMISTRY

Año: 2013; p. 177 - 215

The use of enzymes applied to organic synthesis is gaining more and more relevance due to the mild reaction conditions needed and high selectivities that these catalysts offer. Herein examples about the biocatalyzed synthesis of (chiral) 1,2,3-, 1,2,4-, and benzotriazole-based compounds will be described. While in some cases the enzymatic transformation directly modified these derivatives, in other cases it occurred over a suitable precursor of an interesting triazole-derived target. Finally, some examples about the rational use of one-pot tandem or cascade protocols to synthesize these heterocycles will also be underlined.