Mechanistic insight of the photodynamic inactivation of Escherichia coli by a tetracationic zinc(II) phthalocyanine derivative

M. B. SPESIA; D. A. CAMINOS; P. PONS; E. N. DURANTINI

elsevier

Lugar: London, UK; Año: 2009 vol. 6 p. 52 - 52

p style="TEXT-ALIGN: justify; LINE-HEIGHT: 150%; TEXT-INDENT: 36pt; MARGIN: 0cm 0cm 0pt" class="MsoNormal">Bacterial photodynamic inactivation (PDI) is based in the administration of a photosensitizer, which is preferentially accumulated in the microbial cells. The subsequent irradiation with visible light, in the presence of oxygen, specifically produces cell damages that inactivate the microorganisms. Gram-negative bacteria show a remarkable resistance to negatively charged or neutral agents. This resistance has been ascribed to the presence of highly organized outer membrane, which hinders the interaction of the photosensitizer with the cytoplasmic membrane and intercepts the photogenerated reactive species. In this work, the photodynamic activity of three tetracationic phthalocyanines derivatives were compared in h