NOVEL NIR-PHOTOACTIVE NANOPLATFORM FOR PDT: MAGNETIC/UCNP@mSiO2 CAPPED WITH PORPHYRIN

IGNACIO ROSA-PARDO; MYKHAYLO SEMENOV PETROV; NÉSTOR ESTEBANEZ; DANIEL A. CAMINOS; MARÍA GONZÁLEZ-BÉJAR; RAQUEL E. GALIAN; JULIA PÉREZ-PRIETO

Burjassot Valencia

Workshop; XII International workshop on snesor and molecular recognition; 2018

IDM Instituto Interuniversitario de Reconocimiento Molecular y Desarrollo tecnológico

The integration of different functional materials to lead to materials with relevant features and applications is a subject of increasing interest. Prevously, our group has developed a nanohybrid (Fe3O4@Au@MSN) and decorated with Rose Bengal as PDT photosensitizer, with an efficient singlet oxygen formation upon excitation with visible light [1]. In the present work, a novel biocompatible nanoplatform (NPT) composed of four types of materials with different functionalities has been prepared. The nanohybride combine the properties of magnetic nanoparticles and NIR luminescent upconvertion nanoparticles within m-silica, and decorated with a porphyrin as sensitizer, First, individual magnetic Fe3O4 nanoparticles (MNP) and luminescent core-shell β-NaYF4:Yb3+/Er3+:NaYF4 upconversion nanoparticles (UCNP) were synthesized using already reported methodologies [2,3], and the capture of both NPs into m-silica was optimized The MNP-UCNP@MSN nanohybrid was characterized and then, the surface was functionalized with tetrakis(4-carboxyphenyl)porphyrin previously modified with a linker, (Figure 1). Finally, the NPT was characterized by a battery of techniques such as UV-visible and FTIR spectroscopy, microscopy, magnetism and thermogravimetry and tested as singlet oxygen photosensitizer under NIR excitation. The involved mechanisms will be discussed