CHIA OIL PREVENTIVE THERAPY ADMINISTERED BY ORAL ROUTE TO A PARKINSONIAN RAT MODEL

NARANJO VITERI, ARACELY JANNETH; JÁVEGA COMETTO, MATÍAS; HEREÑÚ, CLAUDIA BEATRIZ; CRESPO, ROSANA

San Luis

Congreso; SAN 2023 Annual Meeting; 2023

Sociedad Argentina de Neurociencias

Parkinson’s disease (PD) is a neurodegenerative disease characterized by theprogressive loss of dopaminergic neurons causing motor and non-motor symptoms.Chia oil (CO) contains α-linolenic acid (ALA) with antioxidant and anti-inflammatoryeffects. The aim of this work was to investigate the effect of CO on the PD 6-OHDAneurodegeneration rat model, by assessing behavioral alterations, clinical andhistological parameters. CO composition was analyzed by CG-MS showing a 63% of ALAcontent. 2-month-old male Wistar rats were injected with 6-OHDA or vehicle throughstereotaxic surgery (week 0). CO (1g/kg/day) was orally administered for 1 week prior tothe 6-OHDA administration (week -1) and for 4 weeks after. Behavioral tests analysisshowed that CO does not modify anxiety parameters but improves cognitive ones. Theanimal weights and their water/food intake decreased the day after surgery andincreased normally afterwards. Physiological parameters were measured in feces, urine,cerebrospinal fluid and serum without significant changes in urine volume, osmolarityand protein content. No toxicological effect was found in liver parameters. Liver, aorta,brain, kidney and small intestine did not show any morphological changes by histologicalanalysis. We conclude that CO treatment did not affect physiological parameters and isa great source of ALA that prevents or decreases neurodegenerative processes andcognitive impairment induced by 6OHDA in the parkinsonian model.