Anticoasgulant effect and action mechanism of sulphated flavonoides from Flaveria bidentis

H.A. GUGLIELMONE, A.M. AGNESE, S.C. NUÑEZ MONTOYA, J.L. CABRERA

THROMBOSIS RESEARCH

Pergamon Press

Año: 2002 vol. 105 p. 183 - 183

0049-3848

font face="AdvTT2cba4af3.B" size="1"> Abstract Quercetin 3-acetyl-7,30,40-trisulphate (ATS) and quercetin 3,7,30,40-tetrasulphate (QTS) obtained from Flaveria bidentis (Asteraceae) wereinvestigated in vitro for anticoagulant activity. Three different concentrations of each flavonoid were assayed at different incubation times,showing at 1 mMsignificant prolongation on the activated partial thromboplastin time (APTT), less on the prothrombin time (PT), and no effect on the thrombin time (TT). In order