Inhibitory effect of quercetin on matrix metalloproteinase 9 activity molecular mechanism and structure.activity relationship of flavonoid-enzime interaction

ALEJANDRA C. SARAGUSTI; MARÍA G. ORTEGA; JOSÉ L. CABRERA; DARÍO A. ESTRIN; MARCELO A. MARTI; GUSTAVO A. CHIABRANDO

ELSEVIER SCIENCE BV

Año: 2010 vol. 644 p. 138 - 138

font face="AdvTT5235d5a9" size="1"> Epidemiological studies have demonstrated an inverse association between the consumption of flavonoid rich diets and the risk of atherosclerosis. In addition, an increased activity of the matrix metalloproteinase 9(MMP-9) has been implicated in the development and progression of atherosclerotic lesions. Even thoughthe relationship between flavonoid chemical structure and the inhibitory property on MMP activity has been established, the molecular mechanisms of this inhibition are still unknown. Herein, we