Photodynamic activity of anthraquinones isolated from Heterophyllaea pustulata Hook f. (Rubiaceae) on MCF-7c3 breast cancer cells

L.R. COMINI, I.M. FERNANDEZ, N.B. RUMIE VITTAR, S.C. NUÑEZ MONTOYA, J.L. CABRERA, V.A. RIVAROLA

ELSEVIER GMBH

Año: 2011 vol. 18 p. 1093 - 1093

font face="GulliverRM" size="1"> Searching for agents that could be effective in the treatment of cancer, special highlight has focused on the study of numerous plant-derived compounds. We previously demonstrated that anthraquinones (AQs) isolated from a vegetal species: Heterophyllaea pustulata Hook f. (Rubiaceae), such as rubiadin, rubiadin-1-methyl ether, soranjidiol, soranjidiol-1-methyl ether exhibit photosensitizing properties without antecedents as photodynamic agents in malignant cells. In the present study, we investigated the potential role of these AQs as a phototoxic agent against human breast carcinoma using MCF-7c3 cells. All AQs exhibited significant photocytotoxicity on cancer cells at the concentration of 100Mwith 1 J/cm