N-demethyl-sauroxine, a novel Lycodine Group alkaloid from Huperzia saururus

MARIANA G. VALLEJO; MARIA GABRIELA ORTEGA; JOSE; L. CABRERA ; ALICIA MARIEL AGNESE

PERGAMON-ELSEVIER SCIENCE LTD

Lugar: Amsterdam; Año: 2013 vol. 54 p. 5197 - 5197

p class="MsoNormal" style="margin: 0cm 0cm 0pt; text-align: justify; line-height: 200%;">The present study describes the isolation and identification of N-demethyl-sauroxine, a novel Lycopodium alkaloid obtained from Huperzia saururus (Lam.) Trevis. (Lycopodiaceae). Its   structure and relative stereochemistry were elucidated on the basis of its spectral data and chemical correlations. Additionally, acetylcholinesterase inhibitory activity was evaluated (IC50 = 209.6 ± 1.1 ìM). The structure of the already identified alkaloid sauroxine was also re-validated through two dimensional NMR data.