PRESSURIZED HOT WATER EXTRACTION OF ANTHRAQUINONES FROM HETEROPHYLLAEA PUSTULATA HOOK F. (RUBIACEAE)

MARIA F. BARRERA VAZQUEZ; LAURA R COMINI; JUAN M MILANESIO; SUSANA C NUÑEZ MONTOYA ; JOSE L CABRERA,; SUSANA BOTTINI; RAQUEL E MARTINI

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 2015 vol. 101 p. 170 - 170

Heterophyllaea Pustulata Hook. f. (Rubiaceae), commonly known as ?cegadera?, is a phototoxic native plantfrom South America, containing anthraquinones with important antibacterial, antiviral and anticanceractivity. In this work, pressurized hot water extraction (PHWE) was applied to extract anthraquinonesfrom the stems of the plant. The effect of temperature, pressure and water flow rate on the extractionyield of four anthraquinones (soranjidiol, rubiadin, rubiadin 1-methyl ether and 2-hydroxy-3-methylanthraquinone) was studied. Within the experimental range explored, the optimum extraction temper-ature was 170◦C. Lower yields were obtained at higher temperatures, apparently due to the thermaldecomposition of these anthraquinones. The experimental extraction curves were fitted with threemodels: the thermodynamic partitioning and the one-site and two-site kinetic models.