Chemical and bioactivity of flavanones obtained from roots of Dalea pazensis Rusby

MARÍA D. SANTI; MARIANA A. PERALTA; CATERINE S. MENDOZA; JOSÉ LUIS CABRERA; MARÍA G. ORTEGA

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

PERGAMON-ELSEVIER SCIENCE LTD

Lugar: Amsterdam; Año: 2017

0960-894X

wo new prenylated flavanones, pazentin A (30,40-dihydroxy-6,20-diprenylpinocembrin, 1) and pazentin B[40-hydroxy-20-methoxy-50-(1000, 1000-dimethylallyl)-6-prenylpinocembrin, 2] together with two knownones (3 and 4) previously isolated from other Dalea species were obtained from the benzene extract ofDalea pazensis Rusby roots. The compounds were evaluated in vitro for their inhibition on mushroomtyrosinase enzyme and in relation to their effect on melanogenesis in B16 murine melanoma cells, byusing a spectrophotometric method. The information obtained could be relevant to the knowledge ofthe structure-activity relationship for these flavonoids with the aim to explore the rational design forskin-whitening agents.