CABRERA JOSÉ LUIS
Capítulos de libros
Título:
Photophysical, photochemical and photobiological properties of anthraquinones isolated from a phototoxic vegetal species: Heterophyllaea pustulata
Autor/es:
LAURA R. COMINI; SUSANA C. NUÑEZ MONTOYA; GUSTAVO A. ARGUELLO; JOSÉ L. CABRERA
Libro:
Trends in Photochemistry and photobiology
Editorial:
Research Trends Publisher
Referencias:
Año: 2010; p. 17 - 36
Resumen:

ABSTRACT

Studies undertaken on isolated photosensitizing

agents from Heterophyllaea pustulata, a phototoxic

plant, which natural habitat is the Northwestern

part of Argentina, are presented here. The

carried out work involved several steps that were

initiated with the chemical-structural study of

their most important secondary metabolites. As a

result, three flavonoids, one iridoid glycoside

(asperuloside) and ten aglycone anthraquinones

were identified. Through the study of the photophysical,

photochemical and photo-biological

properties of the anthraquinone derivatives, we

concluded that they show good photosensitizing

(type I and type II) characteristics. The performed

toxicological assays in vivo showed a direct

cause-effect relation between these metabolites

and the reported phototoxicity for H. pustulata.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

cause-effect relation between these metabolites

and the reported phototoxicity for H. pustulata.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

cause-effect relation between these metabolites

and the reported phototoxicity for H. pustulata.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

cause-effect relation between these metabolites

and the reported phototoxicity for H. pustulata.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

cause-effect relation between these metabolites

and the reported phototoxicity for H. pustulata.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

plant, which natural habitat is the Northwestern

part of Argentina, are presented here. The

carried out work involved several steps that were

initiated with the chemical-structural study of

their most important secondary metabolites. As a

result, three flavonoids, one iridoid glycoside

(asperuloside) and ten aglycone anthraquinones

were identified. Through the study of the photophysical,

photochemical and photo-biological

properties of the anthraquinone derivatives, we

concluded that they show good photosensitizing

(type I and type II) characteristics. The performed

toxicological assays in vivo showed a direct

cause-effect relation between these metabolites

and the reported phototoxicity for H. pustulata.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

cause-effect relation between these metabolites

and the reported phototoxicity for H. pustulata.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

cause-effect relation between these metabolites

and the reported phototoxicity for H. pustulata.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

cause-effect relation between these metabolites

and the reported phototoxicity for H. pustulata.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

cause-effect relation between these metabolites

and the reported phototoxicity for H. pustulata.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

plant, which natural habitat is the Northwestern

part of Argentina, are presented here. The

carried out work involved several steps that were

initiated with the chemical-structural study of

their most important secondary metabolites. As a

result, three flavonoids, one iridoid glycoside

(asperuloside) and ten aglycone anthraquinones

were identified. Through the study of the photophysical,

photochemical and photo-biological

properties of the anthraquinone derivatives, we

concluded that they show good photosensitizing

(type I and type II) characteristics. The performed

toxicological assays in vivo showed a direct

cause-effect relation between these metabolites

and the reported phototoxicity for H. pustulata.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

cause-effect relation between these metabolites

and the reported phototoxicity for H. pustulata.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

cause-effect relation between these metabolites

and the reported phototoxicity for H. pustulata.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

cause-effect relation between these metabolites

and the reported phototoxicity for H. pustulata.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

cause-effect relation between these metabolites

and the reported phototoxicity for H. pustulata.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

plant, which natural habitat is the Northwestern

part of Argentina, are presented here. The

carried out work involved several steps that were

initiated with the chemical-structural study of

their most important secondary metabolites. As a

result, three flavonoids, one iridoid glycoside

(asperuloside) and ten aglycone anthraquinones

were identified. Through the study of the photophysical,

photochemical and photo-biological

properties of the anthraquinone derivatives, we

concluded that they show good photosensitizing

(type I and type II) characteristics. The performed

toxicological assays in vivo showed a direct

cause-effect relation between these metabolites

and the reported phototoxicity for H. pustulata.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

cause-effect relation between these metabolites

and the reported phototoxicity for H. pustulata.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

cause-effect relation between these metabolites

and the reported phototoxicity for H. pustulata.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

cause-effect relation between these metabolites

and the reported phototoxicity for H. pustulata.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

cause-effect relation between these metabolites

and the reported phototoxicity for H. pustulata.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

plant, which natural habitat is the Northwestern

part of Argentina, are presented here. The

carried out work involved several steps that were

initiated with the chemical-structural study of

their most important secondary metabolites. As a

result, three flavonoids, one iridoid glycoside

(asperuloside) and ten aglycone anthraquinones

were identified. Through the study of the photophysical,

photochemical and photo-biological

properties of the anthraquinone derivatives, we

concluded that they show good photosensitizing

(type I and type II) characteristics. The performed

toxicological assays in vivo showed a direct

cause-effect relation between these metabolites

and the reported phototoxicity for H. pustulata.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

cause-effect relation between these metabolites

and the reported phototoxicity for H. pustulata.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

cause-effect relation between these metabolites

and the reported phototoxicity for H. pustulata.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

cause-effect relation between these metabolites

and the reported phototoxicity for H. pustulata.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

cause-effect relation between these metabolites

and the reported phototoxicity for H. pustulata.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Heterophyllaea pustulata, a phototoxic

plant, which natural habitat is the Northwestern

part of Argentina, are presented here. The

carried out work involved several steps that were

initiated with the chemical-structural study of

their most important secondary metabolites. As a

result, three flavonoids, one iridoid glycoside

(asperuloside) and ten aglycone anthraquinones

were identified. Through the study of the photophysical,

photochemical and photo-biological

properties of the anthraquinone derivatives, we

concluded that they show good photosensitizing

(type I and type II) characteristics. The performed

toxicological assays in vivo showed a direct

cause-effect relation between these metabolites

and the reported phototoxicity for H. pustulata.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

cause-effect relation between these metabolites

and the reported phototoxicity for H. pustulata.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

cause-effect relation between these metabolites

and the reported phototoxicity for H. pustulata.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

cause-effect relation between these metabolites

and the reported phototoxicity for H. pustulata.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

cause-effect relation between these metabolites

and the reported phototoxicity for H. pustulata.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

in vivo showed a direct

cause-effect relation between these metabolites

and the reported phototoxicity for H. pustulata.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.

H. pustulata.

Finally, a few words about the potential application

of these photsensitizing compounds as antibacterial

agents will be given.