Photodynamic activity of a new sensitizer derived from porphyrin –C60 dyed and its biological consequences in a human carcinoma cell line

ALVAREZ, G.; PRUCCA, C.; MILANESIO, E.;DURANTINI, E. AND RIVAROLA, V.

PERGAMON-ELSEVIER SCIENCE LTD

Año: 2006 vol. 38 p. 2092 - 2092

font size="1" face="Times-Roman"> The photokilling activity of a porphyrin-C60 (P-C60) dyad was evaluated on a Hep-2 human larynx-carcinoma cell line. This study represents the first evaluation of a dyad, with high capacity to form a photoinduced charge-separated state, to act as agent to inactivate cells by photodynamic therapy (PDT). Cell treatment was carried out with 1 _M P-C60 incorporated into liposomal vesicles. No dark cytotoxicity was observed using 1 _M P-C60 concentration and during long incubation time (24 h). The uptake of sensit