Aflatoxins and fumonisins are synthesized by fungi of the genus Aspergillus and Fusarium, respectively. Aflatoxin B1 (AFB1) and fumonisin B1 (FB1) are the most important in their groups for their impact on food and immunotoxic and carcinogenic effects (Guindon KA et. al., 2008; Silva LJ et. al., 2009). Co-exposure to AFB1 and FB1 is a situation that occurs frequently in nature, in relation to individual exposure to these compounds (González Pereyra ML et. al., 2008). Although the alterations induced by these mycotoxins,
when administered individually, are partially characterised, little is known about the effects induced by both-toxins mixtures. Previously, we have observed different immunobiological effects (Theumer MG et. al., 2003). and alteration of cellular oxidative state after a long-time (24 h) exposure of male Wistar rats spleen mononuclear cells (SMC) to AFB1 and FB1 individually or as a mixture.( Mary VS et. al., 2009).
