COMMUNITY-ASSOCIATED METHICILLIN RESISTANT Staphylococcus aureusHOSPITAL ACQUIRED, ARGENTINA

BARCUDI D; EGEA AL; MRSA GROUP AR; GAGETTI P; FACCONE D; CORSO A; BOCCO JL; SOLA C

Córdoba

Congreso; 52th Annual Meeting Argentine Society for Biochemistry and Molecular Biology; 2016

SAIB

Methicillin-resistantS. aureus(MRSA) burden is increasingly worldwide in hospitals [healthcare-associated (HA)-MRSA] and in thecommunities [community-associated (CA)-MRSA]. The definition of healthcare-onset CA-MRSA infection is based on time fromhospital admission to culture, but the knowledge about the actual time and origin of MRSA acquisition is limited. We aimed todetermine prevalence on admission, acquisition rates and molecular epidemiology of MRSA in Córdoba hospitals, Argentina. Aprospective multicenter study was conducted (October-November 2014) in 8 Córdoba hospitals. Colonization samples were obtainedfrom nasal, pharyngeal and skin swabs from patients at hospital admission and discharge. MRSA were studied by SCC mecand spatyping, PVL, PFGE and MLST. A total of 1419 patients were screened, 58 (4,1%) were colonized by MRSA [44 (3%) CA-MRSA and8 (1%) HA-MRSA], this proportion differed significantly between pediatric (6%) and adult (3%) patients (p<0.0001). The mostfrequent genotypes were associated with PVL+CAMRSA epidemic clones: ST5-IVa-t311 (27%) and ST30-IVc-t019(19%) followedby HAMRSA clones C-ST100-IVNv (15%) and A-ST5-I (7%). Overall MRSA acquisition rate was 2.3/1000 patient days at risk andall these MRSA were CA-MRSA genotypes. These results demonstrate the acquisition and transmission of CA-MRSA strains withinhospitals in our country