Brain Angiotensin II AT1 receptors are involved in the acute and long-term amphetamine-induced neurocognitive alterations

MARCHESE, NATALIA ANDREA; DE LAVILLARMOIS, EMILCE ARTUR; BASMADJIAN, OSVALDO MARTIN; PEREZ, MARIELA FERNANDA; BAIARDI, GUSTAVO; BREGONZIO, CLAUDIA

PSYCHOPHARMACOLOGY

SPRINGER

Año: 2016 vol. 233 p. 795 - 795

0033-3158

ationale: Angiotensin II, by activation of its brain AT1-receptors, plays an active role as neuromodulator in dopaminergic transmission. These receptors participate in the development of amphetamine-induced behavioral and dopamine release sensitization. Dopamine is involved in cognitive processes and provides connectivity between brain areas related to these processes. Amphetamine by its mimetic activity over dopamine neurotransmission elicits differential responses after acute administration or after re-exposure following long-term withdrawal periods in different cognitive processes. Objective: The purpose of this study is to evaluate the AT1-receptor involvement in the acute and long-term amphetamine-induced alterations in long-term memory and in cellular-related events. Methods: Male Wistar rats (250-300 g) were used in this study. Acute effects: Amphetamine (0.5/2.5 mg/kg i.p.) was administered after post-training in the inhibitory avoidance (IA) response. The AT1-receptor blocker