Sex frailty differences in ageing mice: Neuropathologies and therapeutic projections

HERRERA, MACARENA LORENA; BASMADJIAN, OSVALDO MARTIN; FALOMIR LOCKHART, EUGENIA; DOLCETTI, FRANCO JUAN CRUZ; HEREÑÚ, CLAUDIA BEATRIZ; BELLINI, MARÍA JOSÉ

EUROPEAN JOURNAL OF NEUROSCIENCE

WILEY-BLACKWELL PUBLISHING, INC

Año: 2020 vol. 52 p. 2827 - 2827

0953-816X

t is well-established that females live longer than males. Paradoxically, women tend to have poorer health, a condition often named sex frailty. The aim of this study was to evaluate possible frailty predictors in older mice in a sex-specific manner, in order to employ these predictors to follow-up therapy efficiency. To further evaluate therapy effects, we also investigated the use of neurotrophic insulin-like growth factor 1 (IGF-1) gene therapy and its correlation with the expression of this frailty and emotional behaviour. In order to evaluate frailty, we employed two different approaches. We performed a frailty assessment through a 31-Item Clinical Frailty Index and through a Performance-Based 8-Item Frailty Index. Our results show that both indexes are in concordance to evaluate sex differences, but they do not correlate when evaluating IGF-1 therapy effects. Moreover, in order to reduce test-to-test variability for measures of dependent variables, we compared open field results