Brain angiotensin II in dopaminergic imbalance-derived pathologies: neuroinflammaton and vascular responses

OCCHIEPPO, VICTORIA BELÉN; BASMADJIAN, OSVALDO MARTIN; BREGONZIO, CLAUDIA

NEURAL REGENERATION RESEARCH

SHENYANG EDITORIAL DEPT NEURAL REGENERATION RES

Año: 2020

1673-5374

rain angiotensin II (ANG II) as a pleiotropic player: Mental disorders have been commonly associated with an imbalance in many neurotransmiter systems, such as dopamine, glutamate, and gamma-aminobutyric acid. Considering the complexity of brain functioning, all components of theneurovascular unit should be considered in studies for a better comprehension of the physiopathology and possible therapeutcs. ANG II is present in the brain and binds to AT1 receptors (AT1-R), located in the neurovascular unit and has a close relatonship with the mentoned neurotransmiter systems. In pathological conditons, AT1-R expressed in astrocytes, microglia, and brain endothelial cells are key mediators in the development of an oxidatve/ inflammatory microenvironment, as well as in glial activation. Therefore, pharmacological interventon targetng AT1-R provides a holistic and moderated approach to modulate neurotransmission systems in additon to the glial and vascular responses. This interaction is unde