Oxalate induces breast cancer.

ANDRÉS M. CASTELLARO; ALFREDO TONDA; HUGO H. CEJAS; HÉCTOR FERREYRA; BEATRIZ L. CAPUTTO; OSCAR A. PUCCI

BMC CANCER

BIOMED CENTRAL LTD

Lugar: Londres; Año: 2015 p. 1 - 1

1471-2407

ACKGROUND:Microcalcifications can be the early and only presenting sign of breast cancer. One shared characteristic of breast cancer is the appearance of mammographic mammary microcalcifications that can routinely be used to detect breast cancer in its initial stages, which is of key importance due to the possibility that early detection allows the application of more conservative therapies for a better patient outcome. The mechanism by which mammary microcalcifications are formed is still largely unknown but breast cancers presenting microcalcifications are more often associated with a poorer prognosis.METHODS:We combined Capillary Electrochromatography, histology, and gene expression (qRT-PCR) to analyze patient-matched normal breast tissue vs. breast tumor. Potential carcinogenicity of oxalate was tested by its inoculation into mice. All data were subjected to statistical analysis.RESULTS:To study the biological significance of oxalates within the breast tumor microenvironment, we