A sequence similar to bacterial transposable IS elements present in the 5'untranslated region of the bovine butanediol dehydrogenase cDNA

SMANIA A.M,; SALEH M.C.,; ARGARAÑA C.E.

SPRINGER

Año: 1999 vol. 105 p. 203 - 203

sequence similar to prokaryotic transposable elements was identified in the long 5´ untranslated region (5´UTR) of the butanediol dehydrogenase cDNA isolated from a bovine brain λgt11 library. Several observations suggested that this sequence could be related to bacterial IS elements: (a) 58% nucleotide sequence identity, (b) 56% amino acid sequence identity, and (c) the presence of inverted terminal repeats. However, nucleotide sequence analyses of the 5´ UTR bovine cDNA showed the presence of chain-terminating nucleotide substitutions that would renderit incapable of encoding a functional transposase. Finally, it was observed that different vertebrate genomes have sequences related to this putative transposable element.