Autor/es:
DE BRITO, MARIA R.M.; PELÁEZ, WALTER J.; FAILLACE, MARTÍN S.; MILITÃO, GARDENIA C.G.; ALMEIDA, JACKSON R.G.S.; ARGÜELLO, GUSTAVO A.; SZAKONYI, ZSOLT; FÜLÖP, FERENC; SALVADORI, MARIA C.; TEIXEIRA, FERNANDA S.; FREITAS, RIVELILSON M.; PINTO, PEDRO L.S.; MENGARDA, ANA C.; SILVA, MARCOS P.N.; DA SILVA FILHO, ADEMAR A.; DE MORAES, JOSUÉ
Resumen:
xazine derivatives, a class of heterocyclic compounds, exhibit a variety of biological properties, such as anticonvulsant and antitumor activities. In this study, we evaluated the effect of two cyclohexene-fused 1,3-oxazines (cis‑1-benzyl-N-phenyl-1,4,4a,5,8,8a-hexahydro-3,1-benzoxazin-2-imine (1) and trans‑N-phenyl-1,4,4a,5,8,8a-hexahydro-3,1-benzoxazin-2-imine (2)) in cultures of Bacillus cereus, Enterococcus faecalis, Escherichia coli, Klebsiella pneumoniae, Salmonella enterica, Serratia marcescens, Shigella flexneri and Staphylococcus aureus by the Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC). Additionally, the ex vivo antiparasitic activity of oxazines was assessed against Schistosoma mansoni, a helminth that is one of the major agents of the disease schistosomiasis Also, oxazines were evaluated on three tumor cell lines, NCI-H292 (human lung carcinoma), MCF-7 (human breast adenocarcinoma) and HEp-2 (human cervix carcinoma), and