Novel DNA photocleavage properties of [Cr(NN)3]3+ complexes

J. TONEATTO; G. LORENZATTI; ANA M. CABANILLAS; ARGÜELLO, GERARDO ANÍBAL

ELSEVIER SCIENCE BV

Año: 2012 vol. 15 p. 43 - 43

p style="LINE-HEIGHT: 200%; TEXT-INDENT: 35.45pt; MARGIN: 0cm 0cm 0pt" class="MsoPlainText">The aim of this study was to investigate the ability of chromium(III) tris-diimine complexes, [Cr(NN)3]3+, to induce DNA photodamage and to examine its capability to impair the survival of irradiated bacteria with the purpose of using these compounds as photocleavage reagents. [Cr(NN)3]3+ complexes, where NN stands for the ligands: phen (1,10-phenanthroline), 5-Mephen, 4,7-diMephen, 3,4,7,8-tetraMephen, 5-Phphen and 5-Clphen were used for this purpo