the treatment of cancer pathologies1
, thanks to the study and utilization of
transition metal complexes (among other) as photosensitizers.2 Bovine Seric
Albumine (BSA) is a well studied protein due to its ability to act as carrier for number of substrates to the interior of cell. The aim of this work was to study the binding between Bovine Seric Albumine (BSA) and a new cationic cobalt(III) complex, [Co(phen)(H2biim)2]3+ synthesized by Dr. R.
P. Sharma et al.
, thanks to the study and utilization of
transition metal complexes (among other) as photosensitizers.2 Bovine Seric
Albumine (BSA) is a well studied protein due to its ability to act as carrier for number of substrates to the interior of cell. The aim of this work was to study the binding between Bovine Seric Albumine (BSA) and a new cationic cobalt(III) complex, [Co(phen)(H2biim)2]3+ synthesized by Dr. R.
P. Sharma et al.
transition metal complexes (among other) as photosensitizers.2 Bovine Seric
Albumine (BSA) is a well studied protein due to its ability to act as carrier for number of substrates to the interior of cell. The aim of this work was to study the binding between Bovine Seric Albumine (BSA) and a new cationic cobalt(III) complex, [Co(phen)(H2biim)2]3+ synthesized by Dr. R.
P. Sharma et al.
Albumine (BSA) is a well studied protein due to its ability to act as carrier
for number of substrates to the interior of cell. The aim of this work was to
study the binding between Bovine Seric Albumine (BSA) and a new
cationic cobalt(III) complex, [Co(phen)(H2biim)2]3+ synthesized by Dr. R.
P. Sharma et al.
P. Sharma et al.
et al.The fluorescence quenching of the protein by the cationic cobalt(III)
complex at different excitation wavelength and at different temperatures has
been studied. It was observed that both tryptophan as well as tyrosine
residues are involved in the quenching processes, as also observed in our
earlier studies3 . Using the Bhattacharya`s model, association constant (Kb)
were determined which render a value around 9x104 at room temperature.
By the study of Kb at different temperatures and using the Van`t Hoff
equation it was possible to evaluated the thermodynamics parameters. YH=6,65kJ/mol, YS=117,3J/mol.K and YG= -28,3kJ/mol
In conclusion, the complex and the protein bind spontaneously and the association is an endothermic process. According to the thermodynamic parameters, the acting forces are mainly hydrophobic interactions, although the electrostatic attraction cannot be discarded.
were determined which render a value around 9x104 at room temperature.
By the study of Kb at different temperatures and using the Van`t Hoff
equation it was possible to evaluated the thermodynamics parameters. YH=6,65kJ/mol, YS=117,3J/mol.K and YG= -28,3kJ/mol
In conclusion, the complex and the protein bind spontaneously and the association is an endothermic process. According to the thermodynamic parameters, the acting forces are mainly hydrophobic interactions, although the electrostatic attraction cannot be discarded.
By the study of Kb at different temperatures and using the Van`t Hoff
equation it was possible to evaluated the thermodynamics parameters. YH=6,65kJ/mol, YS=117,3J/mol.K and YG= -28,3kJ/mol
In conclusion, the complex and the protein bind spontaneously and the association is an endothermic process. According to the thermodynamic parameters, the acting forces are mainly hydrophobic interactions, although the electrostatic attraction cannot be discarded.
equation it was possible to evaluated the thermodynamics parameters.
YH=6,65kJ/mol, YS=117,3J/mol.K and YG= -28,3kJ/mol
In conclusion, the complex and the protein bind spontaneously and the association is an endothermic process. According to the thermodynamic parameters, the acting forces are mainly hydrophobic interactions, although the electrostatic attraction cannot be discarded.
In conclusion, the complex and the protein bind spontaneously and the
association is an endothermic process. According to the thermodynamic
parameters, the acting forces are mainly hydrophobic interactions, although
the electrostatic attraction cannot be discarded.
