A simple synthesis of benzimidazole N-oxides from 2-nitroaniline derivatives. Scope and limitations.

ELBA I. BUJÁN; MARÍA LAURA SALUM

National Research Council Canada

Lugar: Toronto; Año: 2004 vol. 82 p. 1322 - 1322

everal benzimidazole N-oxide derivatives were synthesized in very good yield by heating at reflux the corresponding N-alkyl-2-nitroaniline derivative with NaOH in 60% 1,4-dioxane-water.  The effect of substituents on the aromatic ring and amino group on the reaction is discussed.