Preparation of benzimidazole N-oxides by a two-step continuous flow process.

NICHOLAS E. LEADBEATER

CHEMISTRY OF HETEROCYCLIC COMPOUNDS

SPRINGER

Lugar: Berlin; Año: 2016 vol. 52 p. 952 - 952

0009-3122

continuous flow process for the synthesis of nitrobenzimidazole N-oxides from 2,6-dinitrochlorobenzene and amines or amino acids is reported. The process, performed in a two-step sequence, is faster than previously reported batch processes and avoids some of the isolation and purification steps.